Endocrine Abstracts

Background: Chronic low-grade inflammation is a major factor in the pathogenesis of type 2 diabetes. One way for promoting inflammatory cytokines secretion is through activation of toll-like receptors (TLR). Their overexpression on monocytes has been demonstrated in insulin resistance and type 2 diabetes. Soluble forms of toll-like receptors (sTLR) are considered a regulatory mechanisms of their activation. Their role has been described in modulation of bacteria-induced infect...

Objective: The beneficial effects of testosterone replacement therapy (TRT) in men with hypogonadism on the body composition and metabolic parametersare well-established, but the intimate mechanisms of these effects are not fully understood. Resistin is a small protein that is involved in the regulation of glucose metabolism and is considered to be key in the development of insulin resistance and to induce proinflammatory effects. We hypothesize that TRT has an impact on the a...

BackgroundBoth obesity and diabetes are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. The aim of the present study was to investigate the circulating levels of IL-18 in different stages of glucose dysregulation from obesity through prediabetes to newly diagnosed diabetesMethodsIL-18 levels were determined using a commercia...

Background: Retinol-binding protein 4 (RBP4) is known as an acute phase inflammatory reactant, associated with insulin resistance. Increased levels of this novel adipokine is observed in obesity, type 2 diabetes mellitus, metabolic syndrome (MetS) and cardiovascular diseases, as well as in nonalcoholic fatty liver disease (NAFLD), but some of these data remain controversial. The aim of this study was to evaluate the relationship between RBP4 and prediabetes in...